What You Still Don’t Know about the $25 Million US National Toxicology Program Study

screenshot from the NTP website.

In 2024, the National Toxicology Program (NTP) announced it had no plans to further study the effects of cellphone radiofrequency radiation (RFR) on human health.

They wanted to find out the US if exposure to radiation from 3G phones can cause the development of malignant cancers. They studied this in lab rats.

Finally, on November 1, 2018, they published their report.

In case you have not read this landmark study, here is a summary of what researchers found:

• 6% of the male rats exposed to the highest dose of cell phone radiation developed malignant schwannomas in the heart, while 2 to 3% developed gliomas in the brain.

Researchers conclusion? “Clear evidence” of cancer and DNA damage from wireless radiation.

—The NTP study took about 10 years to complete in 2018.

Did you know it had taken that long? It started out studying the existing wireless technology used in phones (3G). But the time the study had ended, industry and consumers were moving on to 4G.

—Some did not believe that wireless radiation could cause cancer.

The study had massive detractors. Was such a study was even worth the while?

“The NTP has now shown what no one believed was possible before the project started. The assumption has always been that RF radiation could not cause cancer,” he said, “Now we know that was wrong.”—Ron Melnick told Microwave News.

—The study conclusions would have meant updating FCC’s outdated 1996 standards.

NTP researchers communicated the initial findings to the relevant regulatory agencies, including the FDA and the Federal Communications Commission (FCC), which sets the legal limits for wireless radiation. They had not updated its guidelines since 1996. That’s when we were still using 2G.

But they were not interested to update their guidelines.

—The NTP study sounded the alarm on Schwannomas.

Schwannomas cancer were extremely rare.

Schwannomas are basically what makes your cell’s myelin sheath. It insulates nerve fibers and speed the conduction of electrical impulses.

But it so happened that these same malignant tumors of the heart were also found in another large cell phone rat study published that same year in 2018.

This latter study was carried out at the Ramazzini Institute in Bologna, Italy.

—Researchers decided to publish a follow-up study, or what they excluded from the first study.

Researchers had also found that RFR exposure was associated with an increase in DNA damage. They evaluated DNA damage in three regions of the brain, the liver, and in blood cells in rats and mice. These findings were removed at an earlier timepoint from the ongoing 2-year toxicology study.

They published this second article in October 2019.

DNA damage, if not repaired, can potentially lead to tumors.

This work was included in NTP’s published Technical Reports, but this study includes analyses of the data in the supporting information not included in the Technical Reports.

—Researchers wanted more detailed studies.

The goal of subsequent studies is smaller “mechanistic” studies to understand biological changes related to RFR that could be causing cancer.

—FCC have not explained their current guidelines either.

This is related.

Because at the time, the FCC hasn’t complied with a court-ordered mandate to explain how the agency determined that its current guidelines adequately protect humans and the environment against the harmful effects of exposure to wireless radiation.

—This was government-funded.

It begs the question. Why does it fall to the government to prove harm or no harm? the biological effects of the telecommunication industry’s products.

“[Research] is what the industry should be doing on their dime and using their expertise and their predictions as to where the technology is going.”—Dr Bucher

—Bureaucracy stalled research findings.

FDA to study RFR “because they’re the agency charged with making recommendations to the FCC with respect to the biological aspects of the need for regulation.”

This is in the USA. But similar bureaucratic challenges exist in every government.

—The NTP eventually shut down the studies.

You would have thought they’d be motivated to find out more. After all, EMF exposure are increasingly exponentially and the effects are profound.

No.

In January 2024, the National Toxicology Program (NTP) announced it had no plans to further study the effects of cellphone radiofrequency radiation (RFR) on human health — even though the program’s own $30 million study, which took about 10 years to complete in 2018, found “clear evidence” of cancer and DNA damage.

This article interviews Dr Bucher, a former senior scientist in the National Institute of Environmental Health Sciences (NIEHS) NTP division.

“By the time we would come out with the next generation of studies’ industry would be on to something else. “The government has always been way behind the technologies that are being developed in the telecommunications industries.”—Dr Bucher

—The NTP study reveals how difficult it can be to conduct such studies.

Studying wireless radiation’s biological effects is no small feat.

EMFs as a phenomenon is completely differently from say, drug or environmental chemicals.

NTP scientists had to work with toxicologists, statisticians, geneticists, pathologists, and animal care staff, etc. They also had to work with electrical engineers and experts in wireless radiation to design and build the exposure systems and monitor the exposures used in these studies.

—The final report is redacted.

The National Institutes of Health (NIH) refuses to reveal nearly 2,500 pages of records related to the National Toxicology Program’s (NTP) decision to shut down its research on how wireless radiation affects human health.

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Resources and References:

• NTP’s first paper published on the website. https://ntp.niehs.nih.gov/research/topics/cellphones

• NTP’s second paper evaluated DNA damage in three regions of the brain: Smith-Roe, S.L., Wyde, M.E., Stout, M.D., Winters, J.W., Hobbs, C.A., Shepard, K.G., Green, A.S., Kissling, G.E., Shockley, K.R., Tice, R.R., Bucher, J.R. and Witt, K.L. (2020), Evaluation of the genotoxicity of cell phone radiofrequency radiation in male and female rats and mice following subchronic exposure. Environ Mol Mutagen, 61: 276-290. https://doi.org/10.1002/em.22343

How Bad Is the Air Pollution at Train Stations and Can It Harm Your Health?

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If most of our time is spent indoors, then the next place of significance is our commutes. Many people rely on the public transport system and it may be convenient and ecological. We know the air at these high-traffic urban areas probably is not the best, but how bad is the air pollution and how bad it is for your health?

Studies on Air Pollution at Train Stations

Metro systems play a crucial role in public transportation worldwide. Given that metro stations are unique built environments with a significant volume of daily commuters, ensuring a satisfactory air quality in these spaces becomes paramount.

Small particulates

The general air quality in an urban background already has a particulate matter, but on top of that you have all these extra emissions coming from trains stations. These include particles that come from the carriage moving along the rails, the brake blocks rubbing on the wheels, and the electrical connection between the collector plate and the live rail.

The London Underground, for example, sees up to five million passengers hopping on and off its network. Its 11 lines serve 272 stations, and at peak times there can be over 500 trains hurtling around beneath the streets of London.

All of our fellow passengers, human and otherwise, also contribute to the dust. Hair and skin cells, plastic fibres from clothing, and animal particulates.

Some particles are large enough to be caught by the hairs in our nose and throat, stopping them from getting into our lungs and causing damage there. These are typically referred to as PM10; particulate matter that is under 10 micrometres in diameter, or roughly 0.01mm.

Underground Air Is Worse than Ground-Level

Several studies have reported that particulate matter in underground metro stations were higher than those reported at street-level. In a study of three European metro systems (Barcelona, Athens and Oporto), PM2.5 concentrations in commuter platforms were higher than that in the urban ambient environment (Martins et al., 2016a).

Mean PM2.5 concentrations in underground metro stations in Philadelphia, Pennsylvania, USA, were found to be higher than those at street-level (Shakya et al., 2020).

In Nanjing, China, particle concentrations in underground station concourses were typically higher than those in ambient air (Ji et al., 2021). In Prague, particulate matter concentration levels in the underground metro peaked during rush hour and were found to be highly enriched with iron and other metallic elements during train operating hours (Cusack et al., 2015).

Exposure to Bad Air at Train Stations vs in Cars

While the car isn’t worse than the tube in the case of PM2.5, it is much worse for other pollutants like nitrous oxides.”

It also depends on the design of the train station.

In Singapore, measures such as opting for full-height doors at the platform help maintain air quality on trains and in stations. One study found that PM2.5 levels in the majority of stations exceeded WHO 24-h guideline values.

The PM2.5 & PM10 levels were negatively associated with depth of platforms; the lower the train platforms were underground, the PM2.5, PM10, CO and CO2.

(Being in public areas expose you to other forms of pollution too, such as quats heavily found in almost all typical cleaning supplies. Tube trains and stations are cleaned with hospital-grade cleaning substances that are graded “anti-bacterial”. But this is another article.)

Studies on Indoor Air Quality and Sick-Building Syndrome at Metro Stations

One study looked at the Copenhagen Metro. Ventilation via doors during platform stops caused a drop in observed PM (and CO2) at stations, but the system is surprisingly polluted despite its recent construction.

CO2 mixing ratios ranged from ambient to around 600 ppm. Measures should be taken to control PM levels using a combination of source control and increased clean air supply of the Copenhagen and other similar metro systems.

More Pollution in Low-Humidity Winters

Metro station in Tianjin, China: With a lower relative humidity in winter, the coefficient of friction between railway wheels and rails increased, thus increasing particle emission. The carcinogenic risk of Cr on the platform was unacceptable. Moreover, the health risks induced by Ba should be investigated. The findings indicate that PM control at metro stationss, particularly on platforms in winter, should be emphasized.

Wide Range of Air Pollutants

Study from China, a review of 160 relevant studies performed across over 20 countries: These comprised more than 2000 individual measurement trips. Particulate matters, aromatic hydrocarbons, carbonyls and airborne bacteria have been identified as the primary air pollutants inside metro system:

1. Fe was found as the most dominant element in the metro PM. Mechanical wear at the brake–wheel and wheel–rail interfaces were commonly recognized as the primary PM source in the metro air.

   As for the gaseous pollutants, benzene, toluene, ethylbenzene, xylene, styrene, formaldehyde, acetaldehyde, acetone and acrolein were mostly found in the metro air. Service time of metro system, frequency of passing train, ventilation mode and airflow rate, the age and air-tightness of the metro train, interior materials, the number of passengers and the ambient pollution level outside the metro stations were identified as the key determinants that could play important roles of influencing the metro air quality.

2. The concentrations of aromatic VOCs in new metro carriage were 1-2 times lower than that in the old ones, as higher quality paint were used in new trains.

   Less air circulation and ventilation inside underground carriage was likely the reason of higher VOCs levels than the above-ground track. To reduce the exposure levels of air pollutants, PSDs, air purifier unit, high-efficiency air filter seemed to be effective measures. Among these measures, PSDs have been frequently installed in the newly built metro platforms worldwide.

3. Metro PM showed genotoxicity and ability to induce inflammatory due to large magnetite component. According to the acceptable level proposed by the WorldHealth Organization (1×10−6–1×10−5), the life carcinogenic risk of commuters by subway was sometimes above the acceptable level.

Study: Air Pollution Can Make You Fat

The effects of air pollution is one of the most well-studied topics in the field of environmental toxins research. Air pollution has also been linked to conditions ranging from cardiovascular disease to dementia, Alzheimer's and stroke.

But did you know it can literally make you fat?

The Study

Researchers wanted to find out how exposure to airborne fine particulate matter (diameter, <2.5 μm [PM(2.5)]) pollution impacted adiposity (how fat is laid in the body), as well as metabolic parameters and inflammation. They were interested particularly in exposure during the earlier part of life.

Their breeder at the Ohio State University, Qinghua Sun, had been interested in studying why city-dwellers seem to be at a particularly high risk of heart disease compared to country folk.

It’s common to hear lifestyle habits as a factor in obesity and metabolic diseases. In most cities, a fast food chain is rarely more than a block away, which makes it all too easy to fall in a habit of unhealthy eating.

The breeder wondered if another answer may be hanging, invisibly, in the air we breathe.

To find out more, he started to raise laboratory mice in the kinds of conditions you might find across various cities. Some breathed filtered, clean, air, while others were funnelled the kinds of fumes you might find next to a motorway or busy city centre. Along the way, his team weighed the mice and performed various tests to study how their metabolism was functioning.

Research Findings

After just 10 weeks, the effects were already visible. The rats developed insulin resistance, greater adiposity, and widespread inflammation throughout their body.

• The mice exposed to the air pollution showed greater volumes of body fat, both around the belly and around the internal organs; at the microscopic level, the fat cells themselves were around 20% larger in the mice inhaling a fine mist of pollutants.

• The rats seemed to have quickly become less sensitive to insulin, the hormone that signals to cells to convert blood sugar into energy: the first step towards diabetes.

• The tiny irritating particles may also unleash a flood of inflammatory molecules called “cytokines” to wash through the blood, a response that also triggers immune cells to invade otherwise healthy tissue. Not only does that too interfere with the tissue’s ability to respond to insulin; the subsequent inflammation may also interfere with the hormones and the brain processing that govern our appetite, says Michael Jerrett at the University of California, Berkeley.

This study with laboratory mice offered some of the earliest concrete clues that the effects of air pollution may penetrate far beyond the lungs.

This supports the findings of other studies.

Large studies from cities across the world suggest that humans might be suffering the same consequences.

Chen, for instance, examined the medical records of 62,000 people in Ontario, Canada over a 14-year period. He found that the risk of developing diabetes rose by about 11% for just every 10 micrograms of fine particles in a cubic metre of air.

This is a troubling statistic, considering that the pollution in some Asian cities can reach at least 500 micrograms per cubic metre of air.

In Switzerland, a study saw a similar signs of increased insulin resistance, hypertension, and waist-circumference in a sample of nearly 4,000 people living among dense pollution.

References and Resources:

• Xu X, Yavar Z, Verdin M, Ying Z, Mihai G, Kampfrath T, Wang A, Zhong M, Lippmann M, Chen LC, Rajagopalan S, Sun Q. Effect of early particulate air pollution exposure on obesity in mice: role of p47phox. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2518-27. doi: 10.1161/ATVBAHA.110.215350. Epub 2010 Sep 23. PMID: 20864666; PMCID: PMC3065931.

• https://www.bbc.com/future/article/20151207-the-air-that-makes-you-fat

Air Pollution --- What You Need to Know

Air is a basic for life. But we take it for granted. Air pollution is a fact of most modern living now, and crosses boundaries across countries and into neighbourhood — it is difficult avoid it completely.

It can have serious health consequences over a lifetime. It's pretty grim reading, with impacts ranging from strokes to mental health issues.

But clean air is becoming increasingly rare. To the point that in some cities in the world, doing just 30 minutes of exercise does more harm than good [4].

In recent decades, the Environmental Protection Agency (EPA) in the United States has had great success in improving air quality. The emission of air toxins has declined 74 percent since 1990 [5].

However, by 2019, 82 million American’s were still living in counties that pollution levels still exceed the National Ambient Air Quality Standards (NAAQS).

1. Air Pollution Has Been Well Established as Detrimental to Our Health.
   Respiratory and cardiovascular diseases as well as cancer have been linked to air pollution in urban environments [7].

2. Air Pollution Hurts Cognitive Functions.

   Air pollution acts as a toxin and promotes inflammatory responses, which may cascade into neuroinflammation, dysregulation and neurodegeneration.

   Studies show that air pollution is linked to impaired judgement, mental health problems, poorer performance in school and most worryingly perhaps, higher levels of crime.

   Heavy metals in air is one contaminant that crosses the blood-brain barrier. The air we breathe could be changing our behaviour in ways we are only just beginning to understand.

   In 2011 that Sefi Roth, a researcher at the London School of Economics was pondering the many effects of air pollution. He was well aware of the negative outcome on health, increased hospital admissions and also mortality. But he was staggered to find a clear link between air quality and how well students perform in their examinations! Read more about his study here.
   
   This can be particularly harmful to children. Researchers at an asthma summer camp found that air pollution was significantly and consistently correlated with acute asthma exacerbations, chest symptoms and lung function decrements [8].

   A slew of studies have looked at air pollution and students’ academic performance in schools: Mohai et al. 2011; Grineski et al. 2020; Lu et al. 2021; Berman et al. 2018) and absenteeism (Berman et al. 2018; Zhang et al. 2022)

3. Children Are Especially Vulnerable to Air Pollution

   Our young children are most vulnerable to adverse health effects from air pollution due to smaller physiques, faster rates of respiration, and developing organ systems (Legot et al. 2012; Gauderman et al. 2007; Garcia et al. 2021; Calderón-Garcidueñas et al. 2014).

4. Air Pollution Correlates with Crime and Violence.

   Roth analysed two years of crime data from over 600 of London’s electoral wards, and found that more petty crimes occurred on the most polluted days, in both rich and poor areas.

   We know heavy metals — common in air pollution— is one toxin that predicts more aggressive and violent behaviour in schools.

   Research, led by Jackson Lu of MIT examined nine years of data and covering almost the entire US in over 9,000 cities. It found that “air pollution predicted six major categories of crime”, including manslaughter, rape, robbery, stealing cars theft and assault. The cities highest in pollution also had the highest crime rates. This was another correlational study, but it accounted for factors like population, employment levels, age and gender – and pollution was still the main predictor of increased crime levels.

5. Air Pollution Can Result in Reduced Productivity.

   This 2016 study backed up the above studies as well as Roth’s initial findings that pollution can result in reduced productivity.

6. Air Pollution Can Make You Fat.

   So we know two people can eat the same foods, and do the same exercise, but over the course of a few years, one may put on more weight… It is due to an impaired metabolism (basically how your body makes energy), and air pollution is one major contributor to worsening metabolism.

   Traffic fumes and cigarette smoke are the top culprits because their tiny, irritating particles are able to trigger widespread inflammation and disrupt the body’s ability to burn energy.

   “We are starting to understand that the uptake and circulation of air pollution in the body can affect more than just the lungs,” — Hong Chen, a researcher at Public Health Ontario and the Institute of Clinical Evaluative Sciences in Canada.

7. Particulate Matter (pm2.5) and Nitrogen Dioxide (NO2) - Both of Which Come From Vehicle Exhausts Are Particularly Harmful.

   Fine particulate matter (PM2.5) is comprised of solid and liquid aerosolized particles, so these can deposit deep into the lungs causing oxidative stress and inflammation in several organ systems including the cardiovascular, respiratory, renal, metabolic and neurological systems

   Check out these studies: Bont et al. 2022; Li et al. 2019; Burkart et al. 2022; Delgado-Saborit et al. 2021.

   Researchers couldn’t find any threshold where PM2.5 did no harm, and even those living in the least polluted suburbs of London were affecte.

8. Very Low Amounts of Carbon Monoxide (Co) Can Impair Brain Functions.

   Other air pollutants target the body via separate pathways.

   For example, carbon monoxide (CO) binds exceedingly well with Hemoglobin in the body. Hemoglobin, essential for oxygen delivery, binds with CO 200–300 times more than with oxygen, preventing oxygen from binding to hemoglobin (Patel et al. 2023)!

   CO is a colorless, odorless, and tasteless gas so carbon monoxide poisoning easily occurs, in which the body experiences severe hypoxia. The symptoms include: a shortness of breath, headache, an altered mental status. Finally, it can lead to death (Patel et al. 2023).

   A study of university students exposed to varying levels of CO revealed even low-level exposure resulted in impaired cognition and visual processing (Amitai et al. 1998).

9. Nitrogen Dioxide Can Cause Respiratory Diseases.

   NO2 in air pollution irritates the airways, aggravating including asthma (Epa 2022). It also affect the neurological system, as researchers have found associations between NO2 and dementia (Chang et al. 2014)

10. more than half of the world’s population now live in urban environments – and more of us are travelling in congested areas than ever before.

References and resources:

Rau AT, Harding AB, Ryan A, Ramirez MR, Renner LM, Berman JD. Ambient air pollution and the risk of violence in primary and secondary school settings: a cross-sectional study. Inj Epidemiol. 2024 Jun 13;11(1):24. doi: 10.1186/s40621-024-00512-6. PMID: 38867329; PMCID: PMC11170797.